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Results for "

calcium homeostasis

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Calcium Channel (1) CaSR (1) Apoptosis (2) CGRP Receptor (1) Endogenous Metabolite (1) GHSR (2) Interleukin Related (1) NF-κB (1) p38 MAPK (1) Reactive Oxygen Species (1) TNF Receptor (1) VD/VDR (1)
By Research Areas:	Cancer (2) Endocrinology (2) Inflammation/Immunology (2) Metabolic Disease (4) Neurological Disease (1)

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
Products

Targets Recommended: Calcium Channel CaSR Calmodulin CRAC Channel

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-32343

Secalciferol 3 Publications Verification (24R)-24,25-Dihydroxyvitamin D3	Endogenous Metabolite VD/VDR	Inflammation/Immunology
Secalciferol ((24R)-24,25-Dihydroxyvitamin D3) is the major active metabolite of Vitamin D. Secalciferol is involved in a wide range of biological functions such as calcium homeostasis, cellular differentiation and proliferation processes, as well as other functions related to the immune system .

HY-13964A

YIL781 hydrochloride	GHSR	Metabolic Disease
YIL781 hydrochloride is a potent and orally active ghrelin receptor (GHSR) antagonist. YIL781 hydrochloride produces a greater improvement in glucose homeostasis in rats. YIL781 hydrochloride inhibits the calcium response induced by ghrelin with pIC₅₀ values of 7.90 and 8.27, respectively .

HY-128431

Arochlor 1254	Reactive Oxygen Species	Neurological Disease Metabolic Disease
Arochlor 1254 is a polychlorinated biphenyl (PCB) mixture with biphenyl and 54% chlorine. Aroclor 1254 reduced cell viability and induced overproduction of intracellular reactive oxygen species in a dose-dependent manner. Arochlor 1254 exposure reduces calcium homeostasis, osteoblast differentiation and bone formation .

HY-P6013

wt hMLN

Calcium Channel Others

wt hMLN is a microprotein that inhibits of SR Ca ²⁺ pump (SERCA). wt hMLN plays an important role in skeletal muscle calcium homeostasis .

wt hMLN	Calcium Channel	Others
wt hMLN is a microprotein that inhibits of SR Ca ²⁺ pump (SERCA). wt hMLN plays an important role in skeletal muscle calcium homeostasis .

HY-153258

CaSR antagonist-1	CaSR	Metabolic Disease
CaSR antagonist-1 is a calcium sensing receptor (CaSR) antagonist with an IC₅₀ value of 50 nM. CaSR antagonist-1 can be used for the research of disorders associated with abnormal bone or mineral homeostasis such as osteoporosis .

HY-13964

YIL781	GHSR	Metabolic Disease
YIL781 is a potent and orally active ghrelin receptor (GHSR) antagonist. YIL781 produces a greater improvement in glucose homeostasis in rats. YIL781 inhibits the calcium response induced by ghrelin with pIC₅₀ values of 7.90 and 8.27, respectively .

HY-150968

Antiproliferative agent-11	Apoptosis	Cancer
Antiproliferative agent-11 (compound 7) is an antiproliferative and selective Ruthenium(II)-Tris-pyrazolylmethane complex. Antiproliferative agent-11 shows antiproliferative activity towards MCF-7, HeLa, 518A2, HCT116 and RD with IC₅₀s of 6, 10, 6.8, 6.7 and 6 μM, respectively. Antiproliferative agent-11 can be used for the research of cancer .

HY-103302

SUN B8155	CGRP Receptor	Endocrinology
SUN B8155, a non-peptide agonist of calcitonin (CT) receptor, selectively mimics the biological actions of calcitonin. Calcitonin, a 32-amino acid peptide hormone secreted mainly from the thyroid gland, plays an important role in maintaining bone homeostasis .

HY-N0212

Peimine 1 Publications Verification Verticine; Dihydroisoimperialine	Apoptosis Interleukin Related TNF Receptor p38 MAPK NF-κB	Inflammation/Immunology Cancer
Peimine (Verticine; Dihydroisoimperialine) is an orally active natural product. Peimine has anti-inflammatory, analgesic and cough relieving effects. Peimine can be used in cancer and inflammation related research .

Cat. No.	Product Name

HY-L046

Anti-Cardiovascular Disease Compound Library	1393 compounds
Cardiovascular diseases (CVDs) are a group of disorders of the heart and blood vessels which include coronary heart disease, cerebrovascular disease, peripheral arterial disease, rheumatic heart disease, etc. CVDs are the number 1 cause of death globally. Smoking, unhealthy nutrition, aging population, lack of physical activity, arterial hypertension, or diabetes can promote cardiovascular disease like myocardial infarction or stroke. It is multifactorial and encompasses a multitude of mechanisms, such as eNOS uncoupling, reactive oxygen species formation, chronic inflammatory disorders and abnormal calcium homeostasis. Antioxidant, anti-inflammatory and anti-diabetes agents may reduce the cardiovascular disease risk. MCE supplies a unique collection of 1393 compounds with confirmed anti-cardiovascular activity. These compounds mainly target metabolic enzyme, membrane transporter, ion channel, inflammation related signaling pathways. MCE Anti-Cardiovascular Disease Compound Library can be used for cardiovascular diseases related research and high throughput and high content screening for new drugs.

Anti-Cardiovascular Disease Compound Library

1393 compounds

Cardiovascular diseases (CVDs) are a group of disorders of the heart and blood vessels which include coronary heart disease, cerebrovascular disease, peripheral arterial disease, rheumatic heart disease, etc. CVDs are the number 1 cause of death globally. Smoking, unhealthy nutrition, aging population, lack of physical activity, arterial hypertension, or diabetes can promote cardiovascular disease like myocardial infarction or stroke. It is multifactorial and encompasses a multitude of mechanisms, such as eNOS uncoupling, reactive oxygen species formation, chronic inflammatory disorders and abnormal calcium homeostasis. Antioxidant, anti-inflammatory and anti-diabetes agents may reduce the cardiovascular disease risk.

MCE supplies a unique collection of 1393 compounds with confirmed anti-cardiovascular activity. These compounds mainly target metabolic enzyme, membrane transporter, ion channel, inflammation related signaling pathways. MCE Anti-Cardiovascular Disease Compound Library can be used for cardiovascular diseases related research and high throughput and high content screening for new drugs.

HY-L166

Ion Channel Compound Library	1118 compounds
Ion channel is a membrane-binding enzyme whose catalytic site is an ion conduction pore, which is opened and closed in response to specific environmental stimuli (voltage, ligand concentration, membrane tension, temperature, etc.). Ion channel provide pores for the passive diffusion of ions on the biofilm. Due to their high selectivity for ion, ion channel are generally classified as sodium (Na⁺ ), potassium (K⁺ ), calcium (Ca²⁺ ), chloride (Cl^- ), and non-specific cation channel. Ion channel is an important contributor to cell signal transduction and homeostasis. In addition to electrical signal transduction, ion channel also have many functions: regulating vascular smooth muscle contraction, maintaining normal cell volume, regulating glandular secretion, protein kinase activation, etc. Therefore, dysfunction of ion channel can lead to many diseases, and its mechanism research is particularly important. MCE designs a unique collection of 1118 small molecules related to ion channel, mainly targeting Na⁺ channel, K⁺ channel, Ca²⁺ channel, GABA receptor, iGluR, etc. It is an essential tool for research of cardiovascular diseases, Nervous system diseases and other diseases.

Ion Channel Compound Library

1118 compounds

Ion channel is a membrane-binding enzyme whose catalytic site is an ion conduction pore, which is opened and closed in response to specific environmental stimuli (voltage, ligand concentration, membrane tension, temperature, etc.). Ion channel provide pores for the passive diffusion of ions on the biofilm. Due to their high selectivity for ion, ion channel are generally classified as sodium (Na⁺ ), potassium (K⁺ ), calcium (Ca²⁺ ), chloride (Cl^- ), and non-specific cation channel. Ion channel is an important contributor to cell signal transduction and homeostasis. In addition to electrical signal transduction, ion channel also have many functions: regulating vascular smooth muscle contraction, maintaining normal cell volume, regulating glandular secretion, protein kinase activation, etc. Therefore, dysfunction of ion channel can lead to many diseases, and its mechanism research is particularly important.

MCE designs a unique collection of 1118 small molecules related to ion channel, mainly targeting Na⁺ channel, K⁺ channel, Ca²⁺ channel, GABA receptor, iGluR, etc. It is an essential tool for research of cardiovascular diseases, Nervous system diseases and other diseases.

Cat. No.	Product Name	Target	Research Area

HY-P6013A

wt hMLN TFA

Peptides Others

wt hMLN (TFA) is a microprotein that inhibits of SR Ca ²⁺ pump (SERCA). wt hMLN plays an important role in skeletal muscle calcium homeostasis .

wt hMLN TFA	Peptides	Others
wt hMLN (TFA) is a microprotein that inhibits of SR Ca ²⁺ pump (SERCA). wt hMLN plays an important role in skeletal muscle calcium homeostasis .

HY-P1463A

Calcitonin, eel TFA Thyrocalcitonin eel TFA	Peptides	Others
Calcitonin, eel TFA is the thyroid hormone peptide that contributes to the regulation of calcium homeostasis, widely used in the research of postmenopausal osteoporosis .

HY-P1463

Calcitonin, eel Thyrocalcitonin eel	Peptides	Endocrinology
Calcitonin, eel is the thyroid hormone peptide that contributes to the regulation of calcium homeostasis, widely used in the research of postmenopausal osteoporosis.

HY-P6013

wt hMLN

Calcium Channel Others

wt hMLN is a microprotein that inhibits of SR Ca ²⁺ pump (SERCA). wt hMLN plays an important role in skeletal muscle calcium homeostasis .

wt hMLN	Calcium Channel	Others
wt hMLN is a microprotein that inhibits of SR Ca ²⁺ pump (SERCA). wt hMLN plays an important role in skeletal muscle calcium homeostasis .

HY-P5319

MCaE12A	Peptides	Others
MCaE12A is a high-affinity modulator of RyR2 and increases RyR2 sensitivity to cytoplasmic calcium concentrations promoting channel opening. MCaE12A acts as an important tool for RyR2 structure-to-function studies as well as for manipulating Ca2+ homeostasis and dynamic of cardiac cell .

Secalciferol 3 Publications Verification (24R)-24,25-Dihydroxyvitamin D3	Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Inflammation/Immunology Steroids	Endogenous Metabolite VD/VDR
Secalciferol ((24R)-24,25-Dihydroxyvitamin D3) is the major active metabolite of Vitamin D. Secalciferol is involved in a wide range of biological functions such as calcium homeostasis, cellular differentiation and proliferation processes, as well as other functions related to the immune system .

Peimine 1 Publications Verification Verticine; Dihydroisoimperialine	Alkaloids Piperidine Alkaloids Structural Classification Fritillaria thunbergii Miq. Liliaceae Classification of Application Fields Source classification Plants Inflammation/Immunology Disease Research Fields	Apoptosis Interleukin Related TNF Receptor p38 MAPK NF-κB
Peimine (Verticine; Dihydroisoimperialine) is an orally active natural product. Peimine has anti-inflammatory, analgesic and cough relieving effects. Peimine can be used in cancer and inflammation related research .

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